Total Synthesis of (+)-Niduenes A and B
Abstract
Niduenes A and B, two tetraquinane sesterterpenoids, possess a complex and intriguing 5/5/5/5/6 pentacyclic skeleton with eight contiguous stereocenters. We have achieved the first total synthesis of niduenes A and B in 16 and 14 steps, respectively. The synthesis features a Pauson-Khand reaction to generate the 5/5 bicycle, a Pd-catalyzed oxidative cyclization to construct the congested triquinane framework, and a radical cyclization to assemble the tetraquinane skeleton.
Fields of Study & Subjects
Synthetic Organic Chemistry Methods
Bioactive Natural Diterpenoids Research
Biological Activity of Diterpenoids and Biflavonoids
Publication details
- Journal / source
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Volume
- 148
- Issue
- 26
- Pages
- 27054–27059
- Publication date
- 25 June 2026
- Language
- EN