Silicon-Xanthenium Scaffold for pH- and Far-Red Light Dual-Responsive Photocage
Abstract
The development of far-red light-activatable photolabile protecting groups (PPGs) is crucial for precision medicine applications, yet remains challenging due to the low energy of far-red light photons and the frequent compromise of aqueous solubility. While conditional PPGs activated by specific biochemical conditions offer enhanced spatial control, their scope is limited by the need for external triggers or heterogeneous enzyme expression. Here, we report a new class of dual-responsive PPGs based on a silicon-xanthenium scaffold that are activated by both acidic pH and far-red light. Through systematic structural modification, we developed pcSiR718-OH, a photocage with a low molecular weight (
Fields of Study & Subjects
Photochromic and Fluorescence Chemistry
Nanoplatforms for cancer theranostics
Supramolecular Chemistry and Complexes
Publication details
- Journal / source
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Volume
- 148
- Issue
- 27
- Pages
- 29516–29525
- Publication date
- 29 June 2026
- Language
- EN