Photocatalytic Synthesis of (Hetero)biaryls via Palladium-Catalyzed Hybrid-Radical Cross-Coupling of (Hetero)aryl Halides and C–H Functionalization of Heteroarenes

JACS Au 2026 Open access

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Authors: Sudip Senapati, Sneha Chandra, Lennard Kloene, Claudia Poehner, Claire Empel, Sandip Murarka, René M. Koenigs
DOI: 10.1021/jacsau.5c01634
Cited by: 2
References: 59

Abstract

Light activates palladium catalysts to enable radical C-H (hetero)-arylation of heterocycles using simple (hetero)-aryl halides. Without the need of an external photocatalyst, the reaction proceeds under mild conditions with broad functional-group tolerance and high site selectivity, expanding photoactivated palladium catalysis for sustainable C-C bond formation in complex bi-(hetero)-aryl scaffolds.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Radical Photochemical Reactions Catalytic Cross-Coupling Reactions

Publication details

Journal / source
JACS Au
Publisher
American Chemical Society (ACS)
Volume
6
Issue
2
Pages
1249–1255
Publication date
5 February 2026
Language
EN