Palladium-Catalyzed Enantioselective [4 + 2] Annulation with Allenes: Direct Access to Chiral Silatetralins

JACS Au 2026 Open access

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Authors: Hang Zhou, Yan Sun, Rui Xu, Tao Chen, Liu Gao, Guofeng Zhao, Junliang Zhang, Yidong Wang
DOI: 10.1021/jacsau.6c00146
Cited by: 2
References: 71

Abstract

) bond activation of benzosilacyclobutene. This method exhibits a robust substrate scope, accommodating allenes with alkyl, alkenyl, aryl, silyl, alkoxy, and complex bioactive substituents to deliver enantioenriched functionalized silatetralins. Moreover, the protocol provides direct access to valuable exocyclic methylene-containing silatetralins, serving as versatile intermediates for further synthetic diversification.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Organoboron and organosilicon chemistry

Publication details

Journal / source
JACS Au
Publisher
American Chemical Society (ACS)
Volume
6
Issue
4
Pages
2523–2532
Publication date
9 April 2026
Language
EN