Cytocompatible Biocatalyzed Surface-Initiated PhotoATRP Mediated by Red Light Irradiation in Open Air

JACS Au 2026 Open access

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Authors: Yuwen Zhang, Elena Avanzini, Martina Ferrara, Rebecca Busetto, Veronica Torresan, Alessandro Gandin, Giovanna Brusatin, Cristian Pezzato, Francesca Lorandi, Edmondo Maria Benetti
DOI: 10.1021/jacsau.6c00580
Cited by: 1
References: 46

Abstract

/red light system promotes the controlled growth of chemically different brushes exceeding 300 nm in thickness, while analogous polymerizations in solution proceed in an uncontrolled manner. Mechanistic and calorimetric analyses reveal that the controlled behavior of SI-bioATRP arises from the intrinsic tendency of Hb to physisorb on initiator surfaces and dormant/propagating brush interfaces, ensuring an effective activation-deactivation equilibrium. The resulting process is fully oxygen-tolerant and cytocompatible and operates even in cell-culture media, enabling in situ polymer brush formation under biologically relevant conditions.

Fields of Study & Subjects

Photodynamic Therapy Research Studies Nanoplatforms for cancer theranostics Laser Applications in Dentistry and Medicine

Publication details

Journal / source
JACS Au
Publisher
American Chemical Society (ACS)
Volume
6
Issue
5
Pages
3067–3076
Publication date
29 April 2026
Language
EN