Molybdenum-Catalyzed One-Step Synthesis of Tetrahydroquinolines
Abstract
Through an earth-abundant molybdenum-catalyzed, borrowing hydrogen coupling reaction, a simple and efficient synthesis of tetrahydroquinolines from (2-amino aryl) methanol and α-branched alcohols has been reported. The current methodology proceeds via an atom-efficient and step-economic pathway, along with no need for further reducing agent, broad substrate scope, and operational simplicity, providing a practical and important way for the smooth synthesis of these types of biologically relevant products.
Fields of Study & Subjects
Asymmetric Hydrogenation and Catalysis
Organoboron and organosilicon chemistry
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Precision Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 4
- Issue
- 4
- Pages
- 380–387
- Publication date
- 2 January 2026
- Language
- EN