Access to Fluorene-Fused Isoquinolones Containing an Axially Chiral Element via Cascade Bi-Annulation Reaction of Indene-Dienes

Precision Chemistry 2026 Open access

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Authors: Yan Zhao, Yi-Hang Deng, Ming-Yang Yu, Yinfu Zhang, Wei He, Chuan-Bao Zhang, Qiuxia Han, Ji-Ya Fu
DOI: 10.1021/prechem.5c00356
Cited by: 2
References: 42

Abstract

We report an aromatization-driven organocatalytic cascade bi-annulation of indene-dienes, offering a straightforward route to fluorene-fused isoquinolones containing an axially chiral element. By this strategy, with a chiral organocatalyst, axially chiral pyridyl-substituted derivatives were afforded in moderate to good yields (up to 97% yield, 90:10 er). Alternatively, using DMAP and sodium carbonate as bases, structurally phenyl-substituted fluorene-fused isoquinolones were synthesized in up to 99% yield. This protocol directly constructs two distinct classes of fluorene-fused isoquinolone frameworks.

Fields of Study & Subjects

Axial and Atropisomeric Chirality Synthesis Asymmetric Synthesis and Catalysis Synthesis of Indole Derivatives

Publication details

Journal / source
Precision Chemistry
Publisher
American Chemical Society (ACS)
Volume
4
Issue
5
Pages
632–638
Publication date
26 January 2026
Language
EN