A Dual Photoredox/Cobalt Catalytic System Enables Markovnikov-Selective Hydroaminoalkylation of Alkenes
Abstract
High Resolution Image Download MS PowerPoint Slide We report a visible light-driven dual photoredox/cobalt catalytic system that enables Markovnikov-selective hydroaminoalkylation of alkenes. This cooperative catalysis generates and couples two radical species derived from alkylamines and alkenes via sequential single-electron and proton transfers (SET/PT) from the α-amino C(sp 3 )–H bonds of amines to alkenes. The method enables the installation of secondary or tertiary alkyl groups at α-amino positions of α-amino acid derivatives, peptides, and benzylaniline derivatives using a broad range of alkene partners. This strategy represents a conceptually distinct, redox-neutral, and atom-economical approach to hydrocarbofunctionalization beyond conventional C–H activation pathways.
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Organoboron and organosilicon chemistry
Publication details
- Journal / source
- Precision Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 4
- Issue
- 5
- Pages
- 650–656
- Publication date
- 22 January 2026
- Language
- EN