What does psychopathology research have to gain by studying all mental disorders at the same time?

The 16 constructive commentaries by De Los Reyes (see record 2027-71300-001), Mansell (see record 2027-71300-002), Keyes (see record 2027-71300-003), Hinshaw (see record 2027-71300-004), Harden (see record 2027-71300-005), Giudice (see record 2027-71300-006), Ehrenreich-May and Milgram (see record 2027-71300-007), Pettersson (see record 2027-71300-008), Atkinson et al. (see record 2027-71300-009), South (see record 2027-71300-010), Zalewski et al. (see record 2027-71300-011), Wilson et al. (see record 2027-71300-012), Tackett and Katz et al. (see record 2027-71300-013), Moriarity and Hanson (see record 2027-71300-014), Dalgleish (see record 2027-71300-015), Raballo et al. (see record 2027-71300-016) about our target article (see record 2026-80066-001) offer fresh ideas, new directions, and research questions. Here we amplify points raised about transdiagnostic approaches to etiology, treatment, and prevention; the role of cognitive ability in studying and treating mental disorders; the need to evaluate generational cohort changes in mental disorders; and the importance of assortative mating in life-course research and in treatment. We conclude by laying out a set of domains that would make sense for developing a p-informed measure of life-course vulnerability to psychopathology. (PsycInfo Database Record (c) 2026 APA, all rights reserved).