Immune cells could be protected from ‘exhaustion’ by flipping genetic switches
Abstract
By pinpointing transcription-factor proteins that are selectively engaged when T cells commit to functional or dysfunctional fates, it has been possible to identify regulatory ‘switches’ that drive this decision. Adjusting these switches restored tumour-killing function while preserving memory capacity. Some transcription-factor proteins govern decisions between functional and dysfunctional T-cell states.
Fields of Study & Subjects
T-cell and B-cell Immunology
Cancer Immunotherapy and Biomarkers
Immunotherapy and Immune Responses
Publication details
- Journal / source
- Nature
- Publication date
- 11 February 2026
- Language
- EN