The Physiology Of the WEight Reduced State (POWERS) study: design and rationale for assessment of food intake, physical activity and other behavioral constructs

International Journal of Obesity 2026 Open access

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Authors: Laurel Mayer, Michael R. Lowe, Kelly C. Allison, Maxine Ashby‐Thompson, Giada Benasi, Kyle S. Burger, Roger A. Fielding, Karin Foerde, Dympna Gallagher, John M. Jakicic, Matthew R. Hayes, Christopher E. Kline
+73 more Maren R. Laughlin, Susan B. Roberts, Marie-Pierre St-Onge, Kathryn Whyte, Susan Zelitch Yanovski, Deborah Lee Young-Hyman, Wendy C. King, Leibel Rl, Laurel Mayer, MICHAEL S. ROSENBAUM, Rochelle Goldsmith, Michio Hirano, Charles LeDuc, Christina Roberto, Heather Seid, Marie-Pierre St-Onge, Kathryn Whyte, Yiying Zhang, Alexis O. Aparicio, Daaimah Dratsky, Bret H. Goodpaster, J. W. Gu, Michelle Horowitz, Susan Xiaoqin Lin, Arden L. McMath, Cynthia Mikula, Joel Matos Nunez, Martin Picard, Janet Schebendach, Yifei Sun, Agnes Wong, Wen Wen Yu, Kyle S. Burger, Sai Krupa Das, Roger A. Fielding, M. R. Rickels, David R. Roalf, J. F. Speakman, Gary Wu, Payman L. Zamani, Lillian Chau, Adam Czernuszenko, Cassandra Demastus, Melissa Fernando, Kubarah Ghias, Alexis Gomez, Gabrielle Grosso, Catherine Hambly, Lindsay Herman, Nathaniel Holmes, Andrew Howland, Christina Mastracchio, Sophie Meierovich, Rachel Saks, Varsha Sayana, Mars Scharf, Nicholas Wellman, Edward Williams, Anna Zhou, Olive Zhu, Steven H. Belle, Panayiotis V. Benos, Abdus S. Wahed, Kirk I. Erickson, David Hallam, Tamara L. Haller, Stephanie Sinclair Kelley, Kelsey R. Leonard, Andrew J. Pelesko, Matthew Zourelias, NIH, Bramaramba Kowtha, Susan Zelitch Yanovski
DOI: 10.1038/s41366-025-01991-3
Cited by: 0
References: 65

Abstract

Abstract The Physiology Of the WEight Reduced State (POWERS) study is a multi-center NIH-funded clinical trial designed to determine the physiological basis for variability in weight loss maintenance among adults with obesity following participation in a behavioral weight loss program. Two hundred and five healthy adults, aged 25–

Fields of Study & Subjects

Eating Disorders and Behaviors Regulation of Appetite and Obesity Mobile Health and mHealth Applications

Publication details

Journal / source
International Journal of Obesity
Publication date
9 January 2026
Language
EN