Prevalence and characterization of germline RAS pathway variants in children with chronic myeloid leukemia

Leukemia 2026 Open access

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Authors: Tabita Ghete, Laura Gaschler, Manuela Krumbholz, Stephanie Sembill, Yvonne Lisa Behrens, Axel Karow, Matthias Wölfl, Franziska Auer, Julia Hauer, Maria Giulia Carta, Fulvia Ferrazzi, Stephan Hütter
+4 more Anselm H. C. Horn, Heinrich Sticht, Paul‐Gerhardt Schlegel, Markus Metzler
DOI: 10.1038/s41375-026-02952-z
Cited by: 1
References: 15

Abstract

Genetic predisposition to chronic myeloid leukemia (CML) is not extensively defined, since CML predominantly affects older adults and leukemogenesis is facilitated by age-related accumulation of secondary mutations. Pediatric cases are rare, but studies show that 10% of pediatric patients with CML carry pathogenic germline variants [ 1 ], similar to that observed in myelodysplastic syndrome [ 2 ].

Fields of Study & Subjects

Chronic Myeloid Leukemia Treatments Acute Myeloid Leukemia Research Protein Kinase Regulation and GTPase Signaling

Publication details

Journal / source
Leukemia
Publisher
Springer Science and Business Media LLC
Volume
40
Issue
7
Pages
1527–1531
Publication date
24 April 2026
Language
EN