Synaptic potentiation requires PARP1 activation: prevailing concepts are revisited
Abstract
The therapeutic potential of PARP inhibitors in neurodegenerative diseases of the central nervous system is widely accepted. This prevailing concept is challenged by more recent findings, unveiling the role of PARP1 activity in synaptic long-term potentiation, synaptic plasticity and long-term memory. So, PARP1 inhibition, though intended to prevent memory deterioration, actually interferes with stimulation-induced synaptic plasticity and long-term memory. On the other hand, PARP inhibitors could be useful for preventing mental disorders associated with memory retrieval.
Fields of Study & Subjects
PARP inhibition in cancer therapy
Neuroscience and Neuropharmacology Research
Pharmacological Receptor Mechanisms and Effects
Publication details
- Journal / source
- Molecular Psychiatry
- Publisher
- Springer Science and Business Media LLC
- Volume
- 31
- Issue
- 3
- Pages
- 1837–1843
- Publication date
- 6 January 2026
- Language
- EN