Repeated semaglutide treatment attenuates cocaine-vs-food choice in male and female rats
Abstract
The present study determined the effectiveness of the glucagon-like peptide 1 agonist semaglutide to attenuate cocaine-vs-food choice in male and female rats. Repeated 5-day semaglutide treatment decreased cocaine choice and significantly reduced body weight. These preclinical results support the clinical evaluation of semaglutide as a candidate cocaine use disorder medication.
Fields of Study & Subjects
Diabetes Treatment and Management
Regulation of Appetite and Obesity
Pancreatic function and diabetes
Publication details
- Journal / source
- Neuropsychopharmacology
- Publisher
- Springer Science and Business Media LLC
- Volume
- 51
- Issue
- 7
- Pages
- 1144–1146
- Publication date
- 15 April 2026
- Language
- EN