Outcomes of early-phase ampicillin plus aminoglycosides versus ampicillin plus cefotaxime for preterm infants

Pediatric Research 2026 Open access

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Authors: Hiroki Kitaoka, Takaaki Konishi, Yoshihiko Shitara, Wakana Maki, Atsushi Ito, Kohei Kashima, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Motohiro Kato, Naoto Takahashi, Hideo Yasunaga
DOI: 10.1038/s41390-026-05042-z
Cited by: 1
References: 43

Abstract

BACKGROUND: When used as early empirical antibiotics for preterm infants, ampicillin + aminoglycosides may reduce mortality more effectively than ampicillin + cefotaxime. We compared in-hospital outcomes between early-phase ampicillin + aminoglycoside and ampicillin + cefotaxime therapy. METHODS: Preterm infants (

Fields of Study & Subjects

Neonatal and Maternal Infections Preterm Birth and Chorioamnionitis Antibiotics Pharmacokinetics and Efficacy

Publication details

Journal / source
Pediatric Research
Publisher
Springer Science and Business Media LLC
Publication date
4 May 2026
Language
EN