A microbiota-dependent bile acid reprograms alveolar macrophages to control lung inflammation
Abstract
The human microbiota orchestrates immune responses through both local cell-cell interactions and circulating metabolites. While microbiota-derived metabolites are particularly relevant at sites distal to the intestine, most have been described to act locally in the gut, with only a few, such as short-chain fatty acids or aromatic amino acid derivatives, shown to exert systemic effects. 1 In this context, bile acids stand out for their potential to expand this space: although primarily shown to promote Treg cells and inhibit Th17 responses in the gut, 2 microbial transformations generate a structurally diverse pool of bile acid derivatives, providing a rich platform for discovering compounds capable of shaping immunity at distal sites. 2
Fields of Study & Subjects
Gut microbiota and health
Immune cells in cancer
Drug Transport and Resistance Mechanisms
Publication details
- Journal / source
- Signal Transduction and Targeted Therapy
- Publisher
- Springer Science and Business Media LLC
- Volume
- 11
- Issue
- 1
- Pages
- 35–35
- Publication date
- 17 January 2026
- Language
- EN