Cilium-by-cilium: unveiling hidden proteomic diversity and the molecular basis of ciliopathies
Abstract
In a recent study published in Cell, Hansen et al. applied antibody-based spatial proteomics and advanced confocal imaging to build a comprehensive single-organelle-resolution proteome atlas of the human primary cilium from three cell types —hTERT-RPE1 cells from the embryonic retina, RPTEC/TERT1 cells from the epithelial kidney proximal tubules, and the mesenchymal, multipotent, stromal ASC52telo cells—, identifying 715 proteins and revealing marked cell-type and single-cilium variability. 1 This work demonstrates that primary cilia are highly customizable signaling hubs whose proteomic diversity provides a robust framework for understanding cilia-dependent signaling and uncovering the molecular basis of ciliopathies.
Fields of Study & Subjects
Genetic and Kidney Cyst Diseases
Microtubule and mitosis dynamics
Protist diversity and phylogeny
Publication details
- Journal / source
- Signal Transduction and Targeted Therapy
- Volume
- 11
- Issue
- 1
- Pages
- 14–14
- Publication date
- 10 January 2026
- Language
- EN