Spatial dynamics in health and disease: from neurodevelopment to therapeutic target identification for inflammatory diseases
Abstract
In a recent study published in Nature , Zhang, Rubio Rodríguez-Kirby and colleagues accurately recorded temporal, dynamic changes during brain development revealing the program underlying chromatin accessibility of genes involved in myelination and axonogenesis. 1 By developing an in situ spatial tri–omics platform – spatial ARP-seq and spatial CTRP-seq – at a near single-cell resolution that simultaneously profiles the genome-wide chromatin state, the whole-transcriptome RNA and the proteome, the study unravels the spatiotemporal dynamics of brain development and neuroinflammatory responses, with an atlas of the mouse postnatal brain benchmarked to corresponding regions of the developing human visual cortex. 1
Fields of Study & Subjects
Neuroinflammation and Neurodegeneration Mechanisms
Immune responses and vaccinations
Spondyloarthritis Studies and Treatments
Publication details
- Journal / source
- Signal Transduction and Targeted Therapy
- Publisher
- Springer Science and Business Media LLC
- Volume
- 11
- Issue
- 1
- Pages
- 49–49
- Publication date
- 9 February 2026
- Language
- EN