Exocyst complex regulates fungal-mediated IL-33 release from cancer cells

Signal Transduction and Targeted Therapy 2026 Open access

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Authors: Aftab Alam, Shyamananda Singh Mayengbam, Scott I Abrams, Jun Qu (105401), Prasenjit Dey
DOI: 10.1038/s41392-026-02629-0
Cited by: 1
References: 4

Abstract

Recent studies show that mycobiomes are pervasive in tumors and play a key role in reprogramming the tumor microenvironment. 1 However, the mechanism of intratumor mycobiome-mediated tumorigenesis remains poorly understood and is an evolving area of research. Previously, we have shown that intratumor mycobiome facilitates IL-33 release from Kras-driven pancreatic ductal adenocarcinoma (PDAC) tumor cells, thereby attracting T helper 2 (T H 2) cells and group 2 innate lymphoid cells (ILC2s) in the tumor microenvironment and promoting tumorigenesis. 2 However, the mechanisms underlying fungal-mediated IL-33 release from PDAC cells remain unknown.

Fields of Study & Subjects

IL-33 ST2 and ILC Pathways Eosinophilic Esophagitis Immune Cell Function and Interaction

Publication details

Journal / source
Signal Transduction and Targeted Therapy
Publisher
Springer Science and Business Media LLC
Volume
11
Issue
1
Publication date
6 March 2026
Language
EN