Solid tumors exploit proton-sensing GPR65 for orchestration of an immunosuppressive tumor microenvironment

Signal Transduction and Targeted Therapy 2026 Open access

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Authors: Natalia Truong-Andrievici, Jean−Fred Fontaine, Sebastian Kunz, Barbara Cipriani, Miguel A. Andrade-Navarro, Toszka Bohn, Tobias Bopp
DOI: 10.1038/s41392-026-02717-1
Cited by: 1
References: 6

Abstract

Aggressively growing tumors preferentially rely on anaerobic glycolysis for energy production, resulting in acidification of the tumor microenvironment (TME). Tumor acidosis not only alters the tumor-stroma structure, enhancing invasiveness, 1 but also affects tumor-infiltrating immune cells, such as tumor-associated macrophages (TAM), by promoting a tumor progressive anti-inflammatory polarization. 2 The cellular composition of the TME plays a crucial role for the prognosis of cancer patients and can significantly influence the clinical efficacy of various treatment modalities. 3 Therefore, we sought to understand the molecular basis of acidosis-evoked immune evasion by strongly acidifying tumors.

Fields of Study & Subjects

Sphingolipid Metabolism and Signaling ATP Synthase and ATPases Research Cancer Hypoxia and Metabolism

Publication details

Journal / source
Signal Transduction and Targeted Therapy
Publisher
Springer Science and Business Media LLC
Volume
11
Issue
1
Publication date
14 May 2026
Language
EN