Cryo-EM structures of GPR75 reveal an occluded orthosteric pocket challenging conventional drug discovery paradigms for an anti-obesity target

Acta Pharmacologica Sinica 2026 Open access

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Authors: Zi-ning Zhu, Chongzhao You, Qing‐Ning Yuan, Jiu-yin Xu, Zong-yue Gu, Zheng Huang, Miao Liu, Bei Shan, James Jiqi Wang, Wen Hu, Kai Wang, Wanchao Yin
+3 more Youwei Xu, H. Eric Xu, Canrong Wu
DOI: 10.1038/s41401-025-01720-6
Cited by: 1
References: 32

Fields of Study & Subjects

Receptor Mechanisms and Signaling Diabetes Treatment and Management Protein Kinase Regulation and GTPase Signaling

Publication details

Journal / source
Acta Pharmacologica Sinica
Publisher
Springer Science and Business Media LLC
Volume
47
Issue
5
Pages
1351–1360
Publication date
16 January 2026
Language
EN