A sinomenine derivative protects life-threatening inflammatory injuries via covalently binding to a novel allosteric inhibition site of IRF3

Acta Pharmacologica Sinica 2026 Open access

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Authors: Shuo Li, Bing Xu, Mingjun Lu, Qianwen Wu, Wenqing Qin, Ziqi Dai, Xiaojiaoyang Li, Jin-zhao Bai, Hai-Min Lei, Run-ping Liu

DOI: 10.1038/s41401-025-01723-3

Cited by: 1

References: 54

Fields of Study & Subjects

interferon and immune responses Inflammasome and immune disorders NF-κB Signaling Pathways

References 54