A novel photosensitizer berberine derivative B12 induces apoptosis and suppresses HIF-1α expression in colorectal cancer cells via mitochondria-to-nucleus sequential-targeting

Acta Pharmacologica Sinica 2026 Open access

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Authors: Wen-bin Pei, Ziyu Lei, Fu-quan Xie, Peng Chen, Yong-cheng Su, Yu-shan Qin, J Li, Qian-Wen Shen, Miaomiao Ma, Gao Chun-yi, Jia-chen Zhu, Yajie Xu
+5 more Kai-yue Zhang, Wei Zhang, Yandong Zhang, Tianhui Hu, Beibei Xu
DOI: 10.1038/s41401-025-01728-y
Cited by: 3
References: 81

Fields of Study & Subjects

Photodynamic Therapy Research Studies Porphyrin Metabolism and Disorders Folate and B Vitamins Research

Publication details

Journal / source
Acta Pharmacologica Sinica
Publisher
Springer Science and Business Media LLC
Volume
47
Issue
5
Pages
1249–1269
Publication date
20 January 2026
Language
EN