Regulation of ferroptosis by BAP1

Cell Death and Differentiation 2026 Open access

Read full text
Authors: Kalidou Ali Boubacar, Hind Kahalerras, El Bachir Affar
DOI: 10.1038/s41418-026-01661-5
Cited by: 1
References: 18

Abstract

BRCA1-Associated Protein 1 (BAP1) coordinates both apoptotic and ferroptotic cell death fates through multiple mechanisms. In this issue of Cell Death and Differentiation, Fan et al. show that BAP1 upregulates ACSL4 (long-chain acyl-CoA synthetase 4), increasing incorporation of polyunsaturated fatty acids into phospholipids and amplifying lipid peroxidation, which culminates in ferroptosis. These findings situate ACSL4 as a key effector within the BAP1 signaling network and highlight how a chromatin-linked deubiquitinase can pivotally rewire lipid metabolism to promote ferroptosis [ 1 ].

Fields of Study & Subjects

Ferroptosis and cancer prognosis Trace Elements in Health RNA modifications and cancer

Publication details

Journal / source
Cell Death and Differentiation
Publisher
Springer Science and Business Media LLC
Volume
33
Issue
6
Pages
1100–1102
Publication date
23 January 2026
Language
EN