BOK beyond apoptosis: pyrimidine metabolism and ATR dependence in p53-deficient lung cancer
Abstract
Members of the Bcl-2 (B Cell lymphoma 2) protein family are key regulators of the intrinsic apoptosis pathway triggered by the assembly of permeability pores on the mitochondrial outer membrane (MOM). The family lists more than 15 proteins, functionally divided into pro-apoptotic or anti-apoptotic based on their activity and structural features [ 1 ].
Fields of Study & Subjects
Cell death mechanisms and regulation
Cancer-related Molecular Pathways
DNA Repair Mechanisms
Publication details
- Journal / source
- Cell Death and Differentiation
- Volume
- 33
- Issue
- 9
- Pages
- 1733–1734
- Publication date
- 11 February 2026
- Language
- EN