De novo engineered disulfide bond supersedes native interchain linkage to enhance TCR pairing and anti-tumor efficacy in T cell therapy

Cellular and Molecular Immunology 2026 Open access

Read full text
Authors: Dan Su, Fan Zhu, Hui Shi, Yang Yuan, Yi-Xiang Wang, Xiaoqi Yan, Wei Rui, Guangna Liu
DOI: 10.1038/s41423-026-01418-7
Cited by: 1
References: 48

Fields of Study & Subjects

CAR-T cell therapy research Protein Degradation and Inhibitors Monoclonal and Polyclonal Antibodies Research

Publication details

Journal / source
Cellular and Molecular Immunology
Publisher
Springer Science and Business Media LLC
Volume
23
Issue
6
Pages
686–700
Publication date
30 April 2026
Language
EN