Twin pregnancies are risk factors for both early- and late-onset hypertensive disorders of pregnancy: the Japan Environment and Children’s study

Hypertension Research 2026 Open access

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Authors: Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Yuichiro Miura
+6 more Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito, The Japan Environment and Children’s Study Group
DOI: 10.1038/s41440-025-02502-7
Cited by: 1
References: 56

Abstract

This study investigated the associations of twin pregnancies with early-onset (EO)- and late-onset (LO)-hypertensive disorders of pregnancy (HDP). Totally, 86,717 pregnant women were included in a prospective birth cohort study. The associations of dichorionic diamniotic (DD)- and monochorionic diamniotic (MD)-twin pregnancies with EO-HDP (Diagnosed from 20 to

Fields of Study & Subjects

Pregnancy and preeclampsia studies Assisted Reproductive Technology and Twin Pregnancy Birth Development and Health

Publication details

Journal / source
Hypertension Research
Publisher
Springer Science and Business Media LLC
Volume
49
Issue
4
Pages
1170–1181
Publication date
9 January 2026
Language
EN