The sympathetic nervous system in the pathophysiology of hypertension: Mechanistic insights and therapeutic implications
Abstract
The sympathetic nervous system plays a pivotal role in the pathophysiology of hypertension. Although the contribution of the sympathetic nervous system to an elevation of blood pressure is well established, the determinants of persistent sympathetic overactivity remain incompletely understood. This review summarizes the findings of recent basic research that have expanded the understanding of sympathetic regulation in hypertension, highlighting emerging mechanisms and providing insights into the development of novel therapeutic strategies.
Fields of Study & Subjects
Heart Rate Variability and Autonomic Control
Blood Pressure and Hypertension Studies
Neuroscience of respiration and sleep
Publication details
- Journal / source
- Hypertension Research
- Publisher
- Springer Science and Business Media LLC
- Volume
- 49
- Issue
- 4
- Pages
- 1324–1328
- Publication date
- 19 February 2026
- Language
- EN