Randomized-controlled trial of sacubitril/valsartan and amlodipine combination in Japanese uncontrolled hypertensive patients (J-SAMIT)

Hypertension Research 2026 Open access

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Authors: Kazuomi Kario, Hiromi Rakugi, Chiyo Ito, Sarfaraz Sayyed, Toshihito Kitamura, Yukina Tanaka, Ankur Malhotra
DOI: 10.1038/s41440-026-02704-7
Cited by: 1
References: 26

Abstract

This multicenter, randomized, double-blind, parallel-group, active-controlled study aimed to demonstrate a superior BP-lowering effect of sacubitril/valsartan (SacVal) and amlodipine (AML) combination therapy vs SacVal monotherapy in Japanese patients with grade Ⅰ/Ⅱ essential hypertension inadequately controlled with SacVal monotherapy. After 4 weeks of single-blind active run-in with SacVal 200 mg monotherapy, patients (n=717) with mean sitting systolic blood pressure (msSBP) of 140 to

Fields of Study & Subjects

Blood Pressure and Hypertension Studies Sodium Intake and Health Hormonal Regulation and Hypertension

Publication details

Journal / source
Hypertension Research
Publisher
Springer Science and Business Media LLC
Volume
49
Issue
9
Pages
2587–2600
Publication date
30 June 2026
Language
EN