Electrochemical desulfurative borylation of thiols, disulfides, thioethers and thioacetals

Nature Communications 2026 Open access

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Authors: Julius Kuzmin, Cristiana Margarita, J. Winter, Helena Lundberg
DOI: 10.1038/s41467-025-67363-7
Cited by: 7
References: 99

Abstract

Low-valent sulfur-containing compounds are abundant among natural and synthetic products but remain underutilized as starting materials in desulfurative transformations. Herein, we present thiols, disulfides, thioethers, and thioacetals as precursors in a direct desulfurative electrochemical process for the formation of alkylboronic esters, including late-stage functionalization of pharmaceutically relevant scaffolds and natural products. The electrochemical protocol is simple, user-friendly and scalable, successfully producing gram quantities of borylated product.

Fields of Study & Subjects

Radical Photochemical Reactions Sulfur-Based Synthesis Techniques Organoboron and organosilicon chemistry

Publication details

Journal / source
Nature Communications
Publisher
Springer Science and Business Media LLC
Volume
17
Issue
1
Pages
632–632
Publication date
15 January 2026
Language
EN