A radiolabeled dendrimer non-invasively identifies and tracks innate immune cell activation in a mouse model of experimental autoimmune encephalomyelitis

Nature Communications 2026 Open access

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Authors: Renesmee Kuo, Mackenzie Carlson, Samantha T. Reyes, Sydney C. Nagy, Mausam Kalita, Israt S. Alam, Noeen Malik, Isaac M. Jackson, Christopher Acosta, Irene Falk, E. Carmen Azevedo, Yanrong Zhang
+7 more Lisa Nichols, Corinne Beinat, Naze G. Avci, Madhuri Chattopadhyay, S. Sakura Minami, Jeffrey L. Cleland, Michelle L. James
DOI: 10.1038/s41467-025-67907-x
Cited by: 2
References: 69

Abstract

Non-invasive strategies to detect and track activated myeloid cells will facilitate disease diagnosis and monitoring in patients affected by neuroinflammatory disorders. Here, the authors present 18F-FMD, a dendrimer-based PET tracer that detects and monitors activated myeloid cells at different stages (presymptomatic and symptomatic) of Experimental Autoimmune Encephalomyelitis (EAE) in mice and in response to disease-modifying therapies.

Fields of Study & Subjects

Dendrimers and Hyperbranched Polymers Multiple Sclerosis Research Studies Immunotherapy and Immune Responses

Publication details

Journal / source
Nature Communications
Publisher
Springer Science and Business Media LLC
Volume
17
Issue
1
Pages
1220–1220
Publication date
30 January 2026
Language
EN