CD39 polymorphism enables lung thrombosis in sickle cell disease

Nature Communications 2026 Open access

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Authors: Tomasz Brzóska, Tomasz W. Kamiński, Omika Katoch, E.V. Menchikova, Adekunle Emmanuel Alagbe, Sarah E. Tashbook, Stevan P. Tofovic, Jude C. Jonassaint, Claudette M. St. Croix, Simon C. Watkins, Shane Howe, Joshua J. Field
+15 more A A Seyerle, Tirthadipa Pradhan‐Sundd, Cecilia Laurie, Nathan Pankratz, Smith Nj, Ellen L. Goode, James S. Pankow, Charles Kooperberg, Gregory J. Kato, Yingze Zhang, Enrico M. Novelli, Mark T. Gladwin, Edwin K. Jackson, Mehdi Nouraie, P. Sundd
DOI: 10.1038/s41467-026-68396-2
Cited by: 2
References: 75

Abstract

extracellular vesicles are fewer and ADP-induced platelet aggregation is higher in the blood of SCD patients with rs3176891G allele. This study identifies a novel extracellular vesicle-dependent mechanism preventing lung thrombosis in SCD and reveals how CD39 polymorphisms may impair this protection to increase the risk for lung thrombosis in a subset of SCD patients.

Fields of Study & Subjects

Adenosine and Purinergic Signaling Hemoglobinopathies and Related Disorders Neutrophil Myeloperoxidase and Oxidative Mechanisms

Publication details

Journal / source
Nature Communications
Publisher
Springer Science and Business Media LLC
Volume
17
Issue
1
Pages
1693–1693
Publication date
14 January 2026
Language
EN