A spatially resolved atlas of gastric cancer characterises a lymphocyte-aggregated region

Nature Communications 2026 Open access

Read full text
Authors: Sen Gao, Shishang Qin, Dongfang Wang, Anqiang Wang, Linnan Zhu, Yang Li, Qiang Shi, Hongtao Fan, Yufei Bo, Yunshan Zhong, Yuxuan Sun, Kun Dong
+10 more Liqin Fu, Ranran Gao, Yan Wu, Ye Liang, Luyujie Huang, Xueda Hu, Xianwen Ren, Zhaode Bu, Jiafu Ji, Zemin Zhang
DOI: 10.1038/s41467-026-68612-z
Cited by: 9
References: 52

Abstract

The spatial organisation of the tumour microenvironment (TME) can affect immune responses that control tumour growth. Here, the authors use single-cell transcriptomics and spatial transcriptomics to identify a lymphocyte aggregated region (LAR) in gastric cancer and compare its cellular and molecular composition with the neighbouring TME.

Fields of Study & Subjects

Single-cell and spatial transcriptomics Cancer Immunotherapy and Biomarkers Immunotherapy and Immune Responses

Publication details

Journal / source
Nature Communications
Publisher
Springer Science and Business Media LLC
Volume
17
Issue
1
Publication date
27 January 2026
Language
EN