A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability

Nature Communications 2026 Open access

Read full text
Authors: Shah Alam, Georgia Dermentzaki, David Cabrera-Garcia, 李淼, Ruizhi Wang, Melissa Campbell, Ilaria Balbo, Brittany Lynn Phillips, Min Li, Jessica Estrada, Marianna Zazhytska, Yow-Tyng Yeh
+25 more Lia Min, Elizabeth E. Rafikian, Elizabeth Valenzuela, Brian J. Joseph, Tulsi Patel, Dmytro Ustianenko, Helene Lovett, Huijuan Feng, Xiaojian Wang, Susan Brenner-Morton, Chyuan‐Sheng Lin, Clarissa L. Waites, Hynek Wichterle, Lizhen Chen, Mu Yang, Edmund Au, Marko Jovanović, Stavros Lomvardas, Paul M. Jenkins, Rui Yang, Sheng-Han Kuo, Yueqing Peng, Guang Yang, Neil L. Harrison, Chaolin Zhang
DOI: 10.1038/s41467-026-69486-x
Cited by: 1
References: 103

Abstract

Here researchers reveal a microexon in the Ank3 gene encoding Ankyrin G allows cortical interneurons to fine-tune calcium signaling and firing, revealing the contribution of alternative splicing to the functional diversity among different types of neurons.

Fields of Study & Subjects

Neurogenesis and neuroplasticity mechanisms Bipolar Disorder and Treatment Cellular transport and secretion

Publication details

Journal / source
Nature Communications
Publisher
Springer Science and Business Media LLC
Volume
17
Issue
1
Publication date
13 February 2026
Language
EN