N-nitrosaccharins are not insensitive chemicals
Abstract
Nitroaromatics are essential across many industries (pharmaceuticals, explosives, agrochemicals), driving the search for inexpensive, stable and affordable nitrating agents. Recently, in this journal, Katayev et al. 1 suggested N-nitrosaccharin 1 (2-nitrobenzo[d]isothiazol-3(2H)-one 1,1-dioxide) as a useful source of nitronium ion. Later, the same group demonstrated that 1 and more nitrated relative also synthesized in ref. 1 , 6,N-dinitrosaccharin 2 (2,6-dinitrobenzo[d]isothiazol-3(2H)-one 1,1-dioxide) are efficient agents in nitration of (het)aryl silanes 2 and O -nitration of alcohols and diols 3 . While both nitrosaccharins are undoubtedly useful chemicals, in this correspondence we want to focus the attention of its safety aspects.
Fields of Study & Subjects
Chemical Safety and Risk Management
Energetic Materials and Combustion
Chemical Synthesis and Reactions
Publication details
- Journal / source
- Nature Communications
- Volume
- 17
- Issue
- 1
- Pages
- 1711–1711
- Publication date
- 17 February 2026
- Language
- EN