General and selective ruthenium-catalyzed hydrogenation of primary amides to primary amines under mild conditions

Chakreshwara Kuloor; Vishakha Goyal; Zhuang Ma; Fairoosa Poovan; Dilver Peña Fuentes; Wolfgang Baumann; Jun Zhao; Radek Zbořil; Matthias Beller; Rajenahally V. Jagadeesh

doi:10.1038/s41467-026-69794-2

General and selective ruthenium-catalyzed hydrogenation of primary amides to primary amines under mild conditions

Nature Communications 2026 Open access

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Authors: Chakreshwara Kuloor, Vishakha Goyal, Zhuang Ma, Fairoosa Poovan, Dilver Peña Fuentes, Wolfgang Baumann, Jun Zhao, Radek Zbořil, Matthias Beller, Rajenahally V. Jagadeesh

DOI: 10.1038/s41467-026-69794-2

Cited by: 0

References: 60

Abstract

The catalytic hydrogenation of amides continues to be one of the most difficult reductive transformations in organic synthesis. Here, the authors report Ru-catalyzed hydrogenation of industrially relevant, functionalized, and structurally diverse aromatic, heterocyclic and aliphatic primary amides to produce the corresponding primary amines.

Fields of Study & Subjects

Asymmetric Hydrogenation and Catalysis Nanomaterials for catalytic reactions Organometallic Complex Synthesis and Catalysis

Publication details

Journal / source: Nature Communications
Volume: 17
Issue: 1
Publication date: 5 March 2026
Language: EN

References 60