Cross-ketone deacylative coupling via oxidative SH2 homolytic substitution

Nature Communications 2026 Open access

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Authors: Jianxiong Yang, M. Zhang, Qi Wen, Jia‐Run Wang, Yan Zhang, Heng Jiang
DOI: 10.1038/s41467-026-70619-5
Cited by: 4
References: 72

Abstract

The α-C–C cleavage of ketones provides a versatile route for C–C bond formation but remains challenging, particularly for selective cross-coupling between distinct ketones. Here the authors report a nickel- and photocatalysis-enabled deacylative coupling via bimolecular homolytic substitution to forge diverse C(sp³)–C(sp³) bonds.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Radical Photochemical Reactions Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Nature Communications
Publisher
Springer Science and Business Media LLC
Volume
17
Issue
1
Publication date
19 March 2026
Language
EN