Longitudinal antibody profiling after dengue reveals distinct dynamics by antibody specificity over 18 months

Nature Communications 2026 Open access

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Authors: Sandra Bos, Tulika Singh, José Víctor Zambrana, Elias Michael Duarte, Reinaldo Mercado-Hernandez, Julia Huffaker, Aaron L. Graber, Ángel Balmaseda, Eva Harris
DOI: 10.1038/s41467-026-74406-0
Cited by: 1
References: 61

Abstract

The four dengue virus serotypes (DENV1-4) co-circulate worldwide, posing major challenges for vaccine development. One key issue is that certain levels and subsets of cross-reactive antibodies have been associated with enhanced disease during subsequent infection with a different DENV serotype. To understand the heterogeneity of DENV antibody responses and delineate their distinct kinetics, we define the magnitude and kinetics of 84 antiviral antibody subsets (by isotype, subclass, antigen, and cross-reactivity) after primary versus secondary dengue, using longitudinal samples collected

Fields of Study & Subjects

Mosquito-borne diseases and control Viral Infections and Vectors Malaria Research and Control

Publication details

Journal / source
Nature Communications
Publisher
Springer Science and Business Media LLC
Volume
17
Issue
1
Publication date
20 June 2026
Language
EN