Multifactorial conceptual model of cancer-related accelerated aging

npj Aging 2026 Open access

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Authors: Morse Lh, S. Merrill Weiss, Christine S. Ritchie, Melisa L. Wong, Thomas Karl Hoffmann, Margaret Wallhagen, Christine Miaskowski
DOI: 10.1038/s41514-025-00328-8
Cited by: 1
References: 225

Abstract

Evidence suggests that cancer-related accelerated aging contributes to an earlier onset of chronic diseases; persistent symptoms; and decrements in patients' quality of life. This review presents the Multifactorial Model of Cancer-related Accelerated Aging (MMCRAA), a conceptual framework that is grounded in Life Course Theory and supported by empiric evidence. The model includes six inter-related concepts: person, behavioral, biological, treatment, symptom, and life course factors. The MMCRAA can be used by clinicians and researchers to identify patients at increased risk for cancer-related accelerated aging; guide personalized treatment planning; and inform the development of interventions and research.

Fields of Study & Subjects

Cancer survivorship and care Frailty in Older Adults Cancer-related cognitive impairment studies

Publication details

Journal / source
npj Aging
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Pages
29–29
Publication date
16 January 2026
Language
EN