sc-ChromAging: A Single-Cell Chromatin Accessibility-based Clock Decodes Cell-Type-Specific Epigenetic Aging Trajectories
Abstract
sc-ChromAging, a chromatin accessibility-based aging clock, was developed using single-cell ATAC-seq from 401 Chinese individuals. It identified CD4⁺ naive T cells as the most accurate predictors of age. This clock linked immune aging with pathways in inflammation, infection, and tumor susceptibility, and connecting chromatin changes to plasma metabolites like triacylglycerols.
Fields of Study & Subjects
Single-cell and spatial transcriptomics
Telomeres
Telomerase
and Senescence
Epigenetics and DNA Methylation
Publication details
- Journal / source
- npj Aging
- Publisher
- Springer Science and Business Media LLC
- Volume
- 12
- Issue
- 1
- Publication date
- 9 May 2026
- Language
- EN