Decidual aging in recurrent pregnancy Loss: from regulating networks to therapeutic interventions

npj Aging 2026 Open access

Read full text
Authors: Yu Liu, Wenyan Shi, Zhonglin Jiang, Yujie Xu, Meichen Wang, Xiuju Wang, Hongmei Yin, Dong Wang, Feibo Xu, Yuhui Hao, Dongdong Guan, Lei Han
DOI: 10.1038/s41514-026-00407-4
Cited by: 1
References: 83

Abstract

.The uterine decidua is a key component of the maternal-fetal interface, and its senescence may be an important contributing factor to recurrent pregnancy loss (RPL). Decidual senescence disrupts gestational homeostasis via cell cycle arrest, immune imbalance, and metabolic reprogramming, thereby potentially contributing to RPL. This review offers a new paradigm for understanding RPL etiology, with significant clinical value for improving reproductive outcomes.

Fields of Study & Subjects

Reproductive System and Pregnancy Preterm Birth and Chorioamnionitis Pregnancy and preeclampsia studies

Publication details

Journal / source
npj Aging
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Publication date
19 May 2026
Language
EN