Microbial regulation of intestinal stem cell function: implications for alleviating intestinal injury of weaned piglets

npj Biofilms and Microbiomes 2026 Open access

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Authors: Bo Song, Feilong Deng, Hui Jiang, Meimei Zhang, Jiangchao Zhao, Jianmin Chai, Ying Li
DOI: 10.1038/s41522-026-00973-1
Cited by: 2
References: 86

Abstract

This review highlights how gut microbiota regulates intestinal stem cell function. Weaning stress disrupts this balance, causing intestinal injury in piglets. However, targeted nutritional interventions can modulate the gut microbiota to restore ISC function and repair tissue damage. Understanding this microbe-ISC interaction provides new, effective strategies to improve gut health and alleviate weaning-induced injury in animals.

Fields of Study & Subjects

Animal Nutrition and Physiology Barrier Structure and Function Studies Microbial infections and disease research

Publication details

Journal / source
npj Biofilms and Microbiomes
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Publication date
3 April 2026
Language
EN