Neonatal intensive care unit exposures reprogram microbiome–metabolome trajectories and modulate host calprotectin in preterm infants: a longitudinal multi-omics study

npj Biofilms and Microbiomes 2026 Open access

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Authors: Yihuang Huang, Luyang Hong, Shujuan Li, Lan Zhang, Xinhui Guo, Junyan Han, Weiyin Yu, Huiyu Chen, Ningxin Luo, Jinglin Chen, Wenjing Peng, Yufeng Zhou
+4 more Shangyu Hong, W L Yan, Siyuan Jiang, Y Cao
DOI: 10.1038/s41522-026-01008-5
Cited by: 1
References: 71

Abstract

Early-life gut microbiota development is critical for orchestrating mucosal barrier function and immune priming, as disruptions in this process can increase susceptibility to life-threatening diseases such as necrotizing enterocolitis (NEC) and sepsis. This longitudinal multi-omics study of 186 preterm infants (

Fields of Study & Subjects

Infant Nutrition and Health Neonatal and Maternal Infections Gut microbiota and health

Publication details

Journal / source
npj Biofilms and Microbiomes
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Publication date
14 May 2026
Language
EN