Unraveling the intersection of aging and Parkinson’s disease: a collaborative roadmap for advancing research models

npj Parkinson s Disease 2026 Open access

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Authors: M. Y. Schmidt, A. M. Cuervo, K. L. Double, D. Ehninger, M. S. Goldberg, Kirsten Harvey, J. H. J. Hoeijmakers, K. C. Luk, Pier Giorgio Mastroberardino, D. J. Moore, L. J. Niedernhofer, L. É. Trudeau
+3 more D. Jurk, J. K. Andersen, Ilaria Bellantuono
DOI: 10.1038/s41531-025-01239-x
Cited by: 1
References: 157

Abstract

Aging is the most significant risk factor for Parkinson's disease (PD), yet its role remains underexplored. The International Network for Parkinson's Disease Modelling and Aging (PD-AGE), funded by the Michael J. Fox Foundation, was established to address these challenges. Through collaborative efforts, the PD-AGE mouse-model working group developed a roadmap to prioritize mouse models, reach consensus on experimental approaches, and standardize protocols to investigate the intersection of aging and PD.

Fields of Study & Subjects

Parkinson's Disease Mechanisms and Treatments Nuclear Receptors and Signaling Genetics Aging and Longevity in Model Organisms

Publication details

Journal / source
npj Parkinson s Disease
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Pages
28–28
Publication date
16 January 2026
Language
EN