Parkinson’s disease: spatiotemporal regulation and therapeutic prospects of TREM2-mediated microglial responses

npj Parkinson s Disease 2026 Open access

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Authors: Keyuan Hou, Zhaowu An, Yuxiang Xu, Jing Wang, Meiru Zhou, Ye Liu, Xianfeng Zhu, JianShe Wei
DOI: 10.1038/s41531-025-01247-x
Cited by: 3
References: 144

Abstract

Parkinson's disease (PD) presents a challenge, with neuroinflammation and immune dysregulation central to its pathogenesis. This review examines TREM2-a microglial receptor governing phagocytosis, metabolic adaptation, and immune phenotypes-as an important orchestrator of innate immunity across PD, with roles that appear stage- and context-dependent. We synthesize structure, signaling, and heterogeneity; integrate single-cell multi-omics, animal models, and clinical data; outline conserved mechanisms; and consider translational implications as an investigational biomarker and therapeutic target, emphasizing spatiotemporal dynamics.

Fields of Study & Subjects

Neuroinflammation and Neurodegeneration Mechanisms Inflammation biomarkers and pathways Parkinson's Disease Mechanisms and Treatments

Publication details

Journal / source
npj Parkinson s Disease
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Pages
37–37
Publication date
13 January 2026
Language
EN