Higher-molecular-weight a-synuclein oligomers are increased in the brain cytosol of patients with dementia with Lewy bodies

npj Parkinson s Disease 2026 Open access

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Authors: Emil Gregersen, Mia R. Antorini, Lasse Reimer, Ludovica Zaccagnini, Dennis Selkoe, Tim Bartels, Poul Henning Jensen
DOI: 10.1038/s41531-026-01301-2
Cited by: 1
References: 28

Abstract

The demonstration of MJFR14-6-4-2 proximity ligation assay positive aggregates in brains affected by Parkinson's disease and LRRK2 mutations, motivated the analysis of α-synuclein oligomers in brain cytosol from dementia with Lewy bodies (DLB) and control cases by combining size-exclusion chromatography, aggregate-specific MJFR14-6-4-2 ELISA and SDS-denaturing immunoblotting. We demonstrate a DLB-specific accumulation of large SDS-soluble oligomers, and the presence of medium-sized oligomers consisting of SDS-resistant α-synuclein dimers and trimers in both DLB and controls.

Fields of Study & Subjects

Parkinson's Disease Mechanisms and Treatments Nuclear Receptors and Signaling Alzheimer's disease research and treatments

Publication details

Journal / source
npj Parkinson s Disease
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Publication date
28 February 2026
Language
EN