The biological clock in parkinson’s disease: mechanisms and chronotherapy

npj Parkinson s Disease 2026 Open access

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Authors: Hong Liu, Hao Ling, Kangchao Sun, Kun Yang, Wenzhen Du, Yuxiu Ma, Yaru Wang, Kai Wang, Ying Liu, Long Niu
DOI: 10.1038/s41531-026-01379-8
Cited by: 1
References: 156

Abstract

Circadian disruption is increasingly recognized as a significant contributor to Parkinson's disease (PD) pathogenesis and progression. From a chronobiological perspective, this review synthesizes relevant mechanisms, preclinical/clinical evidence, and highlights chronotherapy's potential in optimizing PD treatment efficacy, reducing side effects, and enabling precision management.

Fields of Study & Subjects

Circadian rhythm and melatonin Parkinson's Disease Mechanisms and Treatments Amyotrophic Lateral Sclerosis Research

Publication details

Journal / source
npj Parkinson s Disease
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Publication date
9 May 2026
Language
EN