Identifying maximal beta power from directional subthalamic local field potentials in Parkinson’s disease

npj Parkinson s Disease 2026 Open access

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Authors: Jennifer K. Behnke, Robert Lucien Peach, Moritz Gerster, Richard M. Köhler, Jeroen Habets, Johannes Leon Busch, Varvara Mathiopoulou, Jonathan Kaplan, Lucia K. Feldmann, Juliette Vivien, Chi Wang Ip, Gerd‐Helge Schneider
+3 more Katharina Faust, Patricia Krause, Andrea A. Kühn
DOI: 10.1038/s41531-026-01380-1
Cited by: 0
References: 22

Abstract

Accurate subthalamic beta activity could guide deep brain stimulation programming in Parkinson's disease, but bipolar recordings complicate contact selection. In 39 patients, we validated three methods to estimate pseudo-monopolar beta power. Distance-weighted methods (Euclidean, Strelow) agreed consistently with the externalized "ground-truth" beta distribution. Maximal beta power across 20s windows was more stable in ring than in directional channels. Beta-contacts from all methods aligned with clinically active stimulation contacts one year after surgery.

Fields of Study & Subjects

Neurological disorders and treatments Neuroscience and Neural Engineering EEG and Brain-Computer Interfaces

Publication details

Journal / source
npj Parkinson s Disease
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Publication date
8 May 2026
Language
EN