Telomere shortening in laminopathic dilated cardiomyopathy

npj Regenerative Medicine 2026 Open access

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Authors: Alex C. Y. Chang, Alex C. Y. Chang, Gaspard Pardon, Andrew C. H. Chang, Andrew C. H. Chang, Chenguang Wang, Vittavat Termglinchan, Анна Кіріллова, Luka Nicin, Foster Birnbaum, Annie Laquerrière, Gisèle Bonne
+2 more Joseph Wu, Helen M. Blau
DOI: 10.1038/s41536-026-00462-1
Cited by: 1
References: 35

Abstract

Laminopathies are a group of rare disease due to mutations in the LMNA gene, which is crucial for nuclear integrity and cellular rigidity. Depending on the mutation, the disease manifests in striated muscles, adipose tissues, nerves, and the heart. Although many laminopathic patients exhibit accelerated aging syndromes, the connection as to why loss of LMNA drives aging remains unknown. Herein, we present evidence that cardiomyocytes from laminopathic heart sections exhibit shortened telomeres. Patient derived hiPSC-CMs we observed LMNA mutation results in myocardial enlargement and altered contractility in cardiomyocytes. Further, laminopathic murine cardiomyocytes recapitulates telomere attrition phenotype.

Fields of Study & Subjects

Nuclear Structure and Function Microtubule and mitosis dynamics Telomeres Telomerase and Senescence

Publication details

Journal / source
npj Regenerative Medicine
Publisher
Springer Science and Business Media LLC
Volume
11
Issue
1
Publication date
10 February 2026
Language
EN