Strategies for enhancing protein solubility: methods, applications, and prospects
Abstract
Controlling protein solubility is critical yet challenging for food and pharmaceutical applications. This review dissects the molecular and environmental determinants governing solubility behavior. It integrates traditional modification strategies with emerging artificial intelligence-driven approaches, emphasizing the transition from empirical trial-and-error to data-driven rational design. This work provides a systematic framework to advance protein engineering solutions across diverse industrial sectors.
Fields of Study & Subjects
Protein purification and stability
Proteins in Food Systems
Advanced Drug Delivery Systems
Publication details
- Journal / source
- npj Science of Food
- Publisher
- Springer Science and Business Media LLC
- Volume
- 10
- Issue
- 1
- Publication date
- 5 February 2026
- Language
- EN